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Police said the blast occurred inside Masjid Rahmania during Friday's prayers.
Speaking to media, the mosque administration said the blast occurred at 1:15pm and that there were approximately 30 to 40 people in the mosque for Friday prayers.
According to initial reports, the explosion shattered windowpanes of the houses nearby. The nature of the blast is yet to be determined.
Police cordoned the area and launched an investigation to ascertain the cause of the explosion.
This is the fifth attack in Balochistan in recent days.
On May 11, at least five people lost their lives in a terror attack targeting the luxury hotel in Gwadar, the army's media wing said in a statement, as it announced the conclusion of its clearance operation of the hotel.
Less than a week later, 14 passengers were offloaded from a passenger bus on the Makran Coastal Highway and shot dead by unidentified assailants.
On May 9, a tribal elder and two others were killed in a blast in Qilla Abdullah, and on May 10, two coal miners and three FC men were martyred in a blast in Khost.
On April 12, 20 people were killed and 48 others injured in the Hazarganji market blast targeting Quetta's Hazara community. The same day, two people were killed in a blast targeting a Frontier Corps vehicle in Chaman.
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